Authors: Fratini, E. ; Palone, F.; Novelli, F. ; Leonardi, S. ; Pasquali, E.; De Stefano, I.; Tanori, M. ; Pinto, R.; Ardoino, L.; Zambotti, A.; Camera, F. ; Merla, C.; Piscitelli, M.; Pazzaglia, S.; Mancuso, M.
BioEM 2025, 22 – 27 June 2025, Rennes, France.
Summary
The skin, as the body’s largest organ, functions not only as a physical barrier but also as a dynamic, immuneresponsive tissue that continuously adapts to environmental stimuli, infections, and injuries. This adaptability
relies on a complex interplay between neuro-mediators, high-affinity receptors, and regulatory proteases, which
collectively maintain tissue integrity and modulate inflammatory responses.
Inflammation in the skin involves intricate interactions among immune cells, cytokines, chemokines, and growth
factors. These factors can drive genetic and epigenetic changes in skin cells, potentially leading to malignant
transformation. Notably, nociceptors and inflammation are closely interconnected: nociceptors not only detect
harmful stimuli but also contribute to the amplification and perpetuation of inflammation. Inflammatory processes
can sensitize nociceptors, heightening their responsiveness, while nociceptor activation, in turn, can further
enhance inflammation.
Given the widespread deployment of 5G technology (FR2 27.5 GHz), understanding its potential role in driving
or modulating inflammatory skin responses is crucial. Evaluating the effects of 5G exposure during the neonatal
period is particularly important, as this stage represents a critical window of physiological and developmental
changes. The skin, nervous system, and immune system are highly dynamic during early life, potentially making
neonates more vulnerable to external influences, including environmental stressors such as 5G radiation.